ez;gu;fSf;F mwpKfg;gLj;j fpspf; nra;aTk;
HIVI jil nra;af;$ba kugZit tpQ;Qhdpfs; milahsk; fz;Lzu;e;Js;sdu;.
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mG+ Ki` |
mnkupf;fhtpd; `hu;tu;l; kUj;Jtf; fy;tp epiyaj;jpy; cs;s tpQ;Qhdpfs; TRIM5 My;gh vd;Dk; kdpj kuG mZ xd;iw milahsk; fz;Ls;sdu;. ,J HIV vdg;gLk; kdpj jLg;G rf;jpia Kwpf;Fk; tp\f;fpUkp clypDs; ,Uf;Fk; jpRf;fis fpUkpj;jd;ikAld; ngUf;fhky; jil nra;Ak; Mw;wiyf; nfhz;Ls;sJ. cldbahf kUj;Jtj; Jiwapy; ngUk; khw;wj;ijf; nfhz;tUk; tha;g;G ,y;iy vd;whYk;> gpg;utup khjk; mwptpf;fg;gl;l ,e;jf; fz;Lgpbg;G HIV Aila tho;f;ifr; Row;rp gw;wp mwptjw;F Kf;fpakhd fl;lkhf ,Ue;J tUq;fhyj;jpy; HIV njhw;Wf;fUkp guthky; jLg;gjw;fhd kUe;ijf; fz;Lgpbg;gjw;Fg; ngupJk; cgNahfkhf ,Uf;Fk;.
nur]; (Rhesus) Fuq;fpd; kuG mikg;ig ed;F Muha;r;rp nra;jjpd; tpisNt ,e;jf; fz;Lgpbg;ghFk;>Fuq;fpzj;jpy; cs;s kuGf; $WghL xd;W HIV I jil nra;af; $Ba Mw;wy; ngw;Ws;sJ vd;gij tpQ;Qhdpfs; ePz;lfhykhfNt mwpe;jpUe;jdu;. 1983k; Mz;L HIV fz;Lgpbf;fg;gl;L rpwpJ fhyk; fle;j clNdNa Muha;r;rpahsu;fs; rpk;gd;rP (kdpj ,dj;NjhL kpf neUf;fkhd njhlu;Gila) Fuq;F tifiaj; jtpu NtW ve;j capupdq;fisAk; HIV jhf;ftpyiy vd;gijf; fz;Lgpbj;jdu;. mg;NghjpUe;Nj ve;j my;yJ vj;jifa kugZf;fs; HIV njhw;iwj; jil nra;a ,aYk; vd;gijg; gw;wpa Muha;r;rp eilngw;W> mjd; tpistpd; %yk; ,ad;w msT kUj;Jt Kiwfis fz;lwpAk; Kaw;rpfs; Nkw;nfhs;sg;gl;L te;jd.
rkPgj;jpa fz;Lgpbg;G upr]; Fuq;fpd; 40>000 kugZf;fis xd;W tplhky; Muha;r;rpf;F cl;gLj;jpa epiyiaf; nfhz;bUe;jJ. gj;J Mz;LfSf;F Kd;G ,t;tpjkhd Muha;r;rpia Nkw;nfhz;bUf;f KbahJ. kdpj ,d kuGj; njhFg;Gfs; (Human Genome Project) vd;w gpuptpy; Ma;Tfspd; %yk; kugZ cj;jpfspy; Vw;gl;Ls;s khngUk; Kd;Ndw;wj;jhy;> kugZf;fis tifg;gLj;jp> Fwpj;Jf; $wf;$ba epiy te;Js;sJ.
`hu;tu;l; kUj;Jtf; fy;tp epiyaj;jpd; khrr;#rl;];> gh];ld; efu Dana Farber Gw;W Neha; fy;tpf; $lj;jpy; ,Uf;Fk; mwptpay; ty;Ydu;fs;> ,e;jf; Fwpg;gpl;lg; GJikahd tif Muha;r;rpia Nkw;nfhz;ldu;. AIDs Muha;r;rpahsuhd N[hrg; Nrhl;Nuh];fp ,e;j Ma;tpw;Fj; jiyik jhq;fpdhu;. `hu;tu;l; kUj;Jf; fy;tp epiya Kidtu; gl;l Kaw;rpahsu; khj;A ];l;nuk;nys gpg;utup khj ,Wjpapy; Nature vd;w tpQ;Qhd ,jopy; te;j mwptpay; fl;Liuapd; jiyik Mrpupauhthu;.
27 tajhd ];l;nuk;nys $Wfpwhu; 'xU itf;Nfhy; Nghupy; Crpiaj; NjbaJ Nghy;jhd; mJ ,Ue;jJ" Kjypy; ,tu; Fuq;fpd; kugZj; njhFg;ig itj;J 40>000 kugZf;fisg; gw;wpa KO tpguq;fis xU E}yfk; Nghy; Nru;j;jhu;. ,J xt;nthd;Wk; gpd;du; kdpj capuZtpy; E}iof;fg;gl;lJ. nghJthf HIV ghjpg;gpw;F clgl;bUe;jJjhd; njhw;wg;gl;be;jpUf;Fk;. gpd; tp\f;fpUkp capuZtpw;Fs; Nru;f;fg;gl;L kugZ njhw;iwj; jLf;Fk; typik nfhz;bUe;jjh? vd;gJ Muhag;gl;lJ.
ghjpf;fg;gl;bUe;j capuZit milahsk; fhz;gjw;fhf `hu;tu;l; FO HIV fpUkp xU gr;irepw xspu; tz;zj;ij ntspapLkhW khw;wp mikj;jdu;. NtW tpjkhff; $wpdhy; ghjpf;fg;gl;l nry;fs; gspnud;w gr;ir epwj;jpy; xspUk;. mijg; gw;wp lhf;lu; Nrhl;Nuh];fp tpsf;fpdhu; 'capUZf;fs; TRIM5 My;ghitf; nfhz;bUe;jit vt;tsT HIV iar; nrYj;jpdhYk; njhw;Wf;F cl;gltpy;iy. mit fWg;ghfNt ,Ue;jd ,J rf;jpAld; HIV iaj; jlj;J epWj;jpaJ".
TRIM5 My;gh kugZ clypd; jLg;G Kiwapd; xU gFjpahff; fUjg;gLk; Gujk; xd;iw cw;gj;jp nra;fpwJ. ,J may; nghUl;fis ,yf;F nfhz;L jhf;fp mtw;wpd; ghjpg;Gj; njhw;Wj;jpwid jilnra;j tpLfpwJ. TRIM5 My;gh Gujj;jpd; kdpj tiff; Fuq;Ffspd; Gujj;Jld; Kw;wpYk; ,izahdit my;y> me;j msT jpwikAld; HIV njhw;iwj; jLf;fTk; mjdhy; KbahJ.
tUq;fhyj;jpy; ,f;fz;Lgpbg;gpd; %yk; tUk; rhj;jpaf; $Efs; gw;wp Nrhl;Nuh];fp $wpdhu; ',e;jg; Gujk; $Ljyhd nraiy Nkw;nfhs;s ce;Jjy; nfhLf;f Kbayhk; mijnahl;b HIV njhw;Wf;F vjpg;G rf;jpfspd; msT ngUf;fg;glyhk;".
TRIM5 My;ghtpd; typik jdpegUf;fpilNa NtWgLk; tha;g;GfSk; cs;sd. gy Mz;Lfshf tpQ;Qhdpfs; Fwpg;gpl;lf;FO kf;fis klLk;> gy Mz;Lfshf tp\f;fpUkp njhw;Wjy; tha;g;G ,Uf;ff;$ba Mdhy; HIV njhw;whj nfd;a (Kenyen) tpiykhju;fs; cl;gl Muha;e;J tUfpd;wdu;. rkPgj;jp fz;Lgpbg;G TRIM5 My;gh Gujk; ,k;kf;fSf;fpilNa njhw;iw vjpu;f;Fk; jd;ikia $Ljyhff; nfhz;bUf;ff;$Lk; vd;w tpsf;fj;ij mspf;fyhk;.
HIv njhw;iwj; jLg;gjpy; TRIM5 My;ghtpd; gq;F ,d;Dk; KOikahf mwpag;gltpy;iy. Mdhy; ,g;Gujk; HIV jd;ikia mWj;J> tp\f;fpUkp jd; fhg;Gr;Rtiu cjpu;f;fhky; nra;af;$Lk;. tp\f;fpUkpapy; kugZ nghUisf; fhf;Fk; tifapy; mijr;Rw;wp xU jLg;ig Vw;gLj;jpAs;s tYthd Gujk;jhd; HIV Aila jd;ikahFk; xU tp\f;fpUkp cs;Ns Eioe;J capuZf;fisj; jhf;Fk;NghJ ,e;jf; fhg;ig cjpu;j;J Gjpa tp\f;fpUkpfs; cw;gj;jpahf tif nra;fpwJ.
TRIM5 My;gh Gujk; ,t;thW "cjpu;jy;" toptifiaj; jLf;ff;$Lk; vd;W Nrhl;Nuh];fp fz;Lgpbj;Js;shu;. 'vt;thW HIV capuZf;fspy; EiofpwJ vd;gJ gw;wp gy Mz;LfshfNt njupe;J tUfpNwhk; rkPgj;jpy; tp\f;fpUkpapd; tho;T Row;rpapd; filrpf; fl;lq;fs;> mJ capuZit ePq;Fk;nghOJ cs;sd vd;W xU rpj;jpuj;ijf; nfhz;Ls;Nshk; Mdhy; tp\f;fpUkp cs;Ns Eiojy;> tp\ RNA- DNA Mf khWjy; ngWfpd;wd vd;git ,d;Dk; ,Uz;lg; gFjpahfj;jhd; cs;sd" vd;W mtu; tpsf;fpdhu;.
mnkupf;fh Njrpa xt;thik kw;Wk; njhw;W tpahjpfs; fy;tpf;$lj;jpd; (US National of Allergy and Ifectious Diserases) ,af;Fduhd Md;ldp ngsf;fp vd;gtupd; fUj;jpd;gb ,f;fz;Lgpbg;G 'HIV jPtpukiltjw;F Kd;Ng njhw;wpd; njhlf;ff; fl;lq;fspy; jiyapLtjw;F Gjpa tiffisf; fhl;Lfpd;wJ".
TRIM5 My;gh kugZ cw;gj;jp nra;Ak; ,e;jg; Gujk;> njhw;iwj; jLg;gjw;F jdp capuZf;fSf;Fs; nray;gLk; xU Cf;fpapd; Kjy; cjhuzkhFk;. clypd; kw;wj; jLg;Gr; rf;jpapd; $WghLfs; anti-bdoies nts;is ,uj;j mZf;fs; Mfpait ,uj;j Rj;jpfupg;G Kiwapy; may; nghUl;fis mopj;J tpLfpd;wd.
TRIm Kila kw;iwa cl;gFjpfs; gy Mz;LfshfNt fz;lwpag;gl;litahFk;. Mdhy; mtw;wpd; gad;ghLfs; ,Jtiu njupahky; ,Ue;J te;jd. 'ehq;fs; cz;ikapy; fz;Lgpbj;J tUtJ ,aw;if Kiwapd; ghJfhg;G mk;rq;fs; gw;wpahFk;. ,it HIV jtpu kw;w tp\f;fpUkpfSf;F vjpuhfTk; nray;gl;L tuf;$Lk;. ehq;fs; 'Kjy; cjhuzj;ij" ,q;F ghu;j;J tUfpNwhk; ,aw;ifapy; ,J xd;Wjhd; cjuhzkhf ,Uf;Fk; vd;W ehd; epidf;ftpy;iy" vd Nrhl;Nuh];fp tpsf;fpdhu;.
HIV vd;gJ kW ,af;f tp\f;fpUkpfs; (Retroviruses) vd;w gpupitr; rhu;e;jjhFk;. ,it cs;NsNa 'cw;gj;jp nra;Ak;" capuZf;fis Gjpjhf gyKiw gpwg;gpf;fr; nra;Ak; tifapy; ,lk; nfhLf;Fk; capuZf;fisf; nfhd;W jhNk cly; KOtJk; guTk; rf;jpiaAk; cilait Mifahy; Fwpg;gplj;jf;f tifapy; jPaj; njhw;Wf;fs; MFk;. jq;fSila ePz;lfhy gupzhk tsu;r;rpapy; Fl;b Nghl;L ghy; nfhLf;Fk; capupdq;fs; ,j;jifa fpUkpfisj; jhq;fpAs;sd. Mdhy; mtw;wpd; jPa tpisTfis mfw;Wk; tifapy; mit gpwg;gpj;Jf; nfhs;s Kbah tifapy; mjpf msT kugZf;fis tsu;j;jpUf;f Ntz;Lk;.
',e;j kuG mZf;fs;> ehk; mwpe;jtiu (TRIM-My;gh Nghd;wit) ntbj;Jg; ngUFk; jd;ikAlit> tp\f;fpUkpfis vjpu;f;Fk; Mw;wYilait" vd;W lhf;lu; ];B/gd; Nfhg; vd;Dk; nfhyk;gpa gy;fiyf;fof capupay; ngsjPfg; Nguhrpupau; $wpAs;shu;. 'xUNtis mit mf;fhuzj;jpdhNyNa tsu;e;jpf;fTk; $Lk;".
vdNt ,e;jr; rkPgj;jpaf; fz;Lgpbg;G Muha;r;rp cyfpy; xU Gjpa tha;g;ig Vw;gLj;jpAs;sJ. kw;w kugZf;fs;> Gujq;fs; ,tw;iw milahsk; nfhs;sTk;> mit vt;thW Fwpg;gpl;l tp\f;fpUkpfSf;F vjpuhfr; nray;gLk; vd;gJ gw;wpj; jfty; nfhLj;Jk;> nfhba> nfhy;Yk; tpahjpfspd; jPtpuq;fisf; Fiwg;gjw;Fk; - vjpu;g;gjw;Fk; Gjpa tiffis tsu;g;gjw;F mbg;giliaf; nfhLf;ff;$Lk;.
jkpo; ,];yhkpa nra;jp Clfk;